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A 2015 analysis of six studies found little evidence that long-term or regular cannabis smoking was associated with lung cancer risk, though it could not rule out whether an association with heavy smoking exists.
Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation.
Evidence for causing these cancers is mixed concerning heavy, long-term use.
In general there are far lower risks of pulmonary complications for regular cannabis smokers when compared with those of tobacco.
It was also shown that giving THC or cannabis correlated with increased bloodflow in these areas, and facilitated activation of the anterior cingulate cortex and frontal cortex when participants were presented with assignments demanding use of cognitive capacity.
Both reviews noted that some of the studies that they examined had methodological limitations, for example small sample sizes or not distinguishing adequately between cannabis and alcohol consumption.
A 2012 meta-analysis found that the effects of cannabis use on neurocognitive functions were "limited to the first 25 days of abstinence" and that there was no evidence that such use had long-lasting effects, Compared to non-smokers, people who smoked cannabis regularly in adolescence exhibit reduced connectivity in specific brain regions associated with memory, learning, alertness, and executive function.
If cannabis arteritis turns out to be a distinct clinical entity, it might be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC.
In a survey of heavy users, 42.4% experienced withdrawal symptoms when they tried to quit marijuana, such as craving, irritability, boredom, anxiety and sleep disturbances.
About 9% of those who experiment with marijuana eventually become dependent.
sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use.
Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.