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To test that hypothesis, Diamond again turned to work in both humans and animals. Conditions under which young children CAN hold two rules in mind and inhibit a prepotent response. doi:10.1037//0012-1649.38.3.352 PMID:12005379 (abstract) (pdf) Diamond, A.

Diamonds team studied children and animal models, combining neurochemical and behavioral work in animals --creating the first animal model of treated PKU along the way -- with longitudinal testing of an extensive battery of neurocognitive tasks in infants and children. Diamonds team had found converging evidence from two very different domains, vision and cognition, in support of her hypothesis about the mechanism causing cognitive deficits in PKU children when their Phe levels were maintained at what had been thought to be safe levels (3-5 times normal; 360-600 μmol/L). PFC cognitive deficits were closely related to childrens levels of Phe. The deficit in contrast sensitivity was closely related to what the childrens Phe levels had been during the first month of life. Sorting between theories of perseveration: Performance in conflict tasks requires memory, attention, and inhibition [Response]. doi:10.1111/1467-7687.00300 (abstract) (pdf) Diamond, A., Lee, E-Y., & Hayden, M. Early success in using the relation between stimulus and reward to deduce an abstract rule: Perceived physical connectedness is key. doi:10.1037/0012-1649.39.5.825 PMID:12952397 (abstract) (pdf) Diamond, A., Kirkham , N.

One of those relates to attention-deficit hyperactivity disorder (ADHD).

We predict, and are testing, that physicians prescribing the correct dose of psychostimulants for controlling hyperactivity in patients with ADHD are prescribing too high a dose for patients cognitive problems.

Researchers and educators tend to focus on one aspect of a person in isolation. (abstract) (pdf) Zagreda, L., Goodman, J., Druin, D.

For example, efforts to study or to improve cognitive skills (such as EFs) or academic performance are generally done ignoring whether participants are happy or sad, lonely or healthy. Human brain development: Perception, attention, and memory.

Building on that insight, she undertook a systematic program of research to chart the developmental progression of human infants on A-not-B and delayed response plus a transparent barrier task (to obtain converging evidence from a very different paradigm), the developmental progression of infant monkeys on the 3 tasks, the effect of lesions on adult monkeys' performance of those tasks, and the effect of lesions on infant monkeys' performance of the tasks (see Table below). It also fundamentally altered the scientific understanding of PFC early in development; clearly it was not silent as accepted wisdom had held. A model system for studying the role of dopamine in prefrontal cortex during early development in humans. Recently we have turned our attention to the possible roles of music, dance, storytelling, traditional martial arts, positive sports, yoga, mindfulness, and even circus for improving executive functions, academic outcomes and mental and physical health. [up] [home] Adele Diamonds work opened up a new field of inquiry, Developmental Cognitive Neuroscience, which marked a milestone in the integration of developmental psychology, cognitive science, and neuroscience. Social and/or emotional aspects of, or adjuncts to, a program to improve cognitive skills might be key to whether and/or how much that program succeeds. We hope our research might fundamentally change the approach and underlying assumptions (i.e., shift the paradigm) of how to improve cognitive skills and how to educate children.

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