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Cystic fibrosis only occurs when both copies of the CFTR gene contain a mutation—this is why cystic fibrosis is called an autosomal recessive disease, as opposed to an autosomal dominant disease (in which only one copy of the mutated gene is needed for disease development).The clincher is if you and your partner are both CF carriers, you could pass CF on to your child.

With a sweat chloride test, the salt content of the baby's sweat is measured.This is because your child will inherit one chromosome of each pair from you, and one from your partner.If your child gets both copies of the chromosome containing the mutated CFTR gene, they will have two mutated copies and will be born with cystic fibrosis.If your partner is not a CF carrier, it will be impossible for your child to have CF because he can only inherit normal copies of the CFTR gene from your partner.However, if your child received the mutated CFTR gene from you, he or she will have a 25 percent chance of being a carrier.

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